It now tries to find your IP address every time MFME starts up ( Win7 version), if it's not picking the correct one enter it manually and click the static checkbox to prevent it from being changed.
The best solution is to add a loop back interface to your comms adaptors in the control panel and give it a static address like 10.11.12.13 and then enter that in the box and click static. There is a thread explaining this on here somewhere.
This thread if anyone needs it...
http://www.fruit-emu...mes-mfme-v6-v5/
As noted, you'll need to allow MFME through your local firewall as well if enabled...